-transparent.png){kind=logo}
Catalase is the major peroxisomal H2O2-detoxifying enzyme and is thought to be critical in maintaining low H2O2 levels within a cell. It has been proposed that increased H2O2 levels may be involved in oxidative DNA damage and tumor promotion induced by peroxisome proliferators and other xenobiotics. To develop a mouse model system to address this issue, we have generated transgenic mice that exhibit a three- to four-fold increase in liver catalase levels. The activities of fatty acyl coenzyme A (CoA) oxidase and lauric acid hydroxylase were unchanged in transgenic mice, demonstrating that elevated catalase levels did not alter the activity of these other peroxisome proliferator-induced enzymes that produce active oxygen. These mice should help elucidate the role of H2O2 in cellular events mediated by peroxisome proliferators and other xenobiotics.
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
April 2013,
Reproductive toxicology (Elmsford, N.Y.),
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
January 1963,
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
October 1997,
Age,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
March 1953,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
January 1961,
Neoplasma,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
April 1998,
Carcinogenesis,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
June 2004,
Transgenic research,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
December 1974,
The Tohoku journal of experimental medicine,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
March 1960,
Gan,
V Nilakantan, and
Y Li, and
H P Glauert, and
B T Spear
June 1972,
Cancer research,
