-transparent.png){kind=logo}
Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists. 1995
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
Department of Medicinal Chemistry, Glaxo-Wellcome, Stevenage, Hertfordshire, UK.
A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective alpha 2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analogue (fluparoxan).
Related Publications
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
June 1988,
European journal of pharmacology,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
August 1987,
Journal of medicinal chemistry,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
December 1983,
Journal of medicinal chemistry,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
January 1978,
Journal of medicinal chemistry,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
August 2006,
Bioorganic & medicinal chemistry letters,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
January 1987,
Psychopharmacology series,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
June 1998,
Bioorganic & medicinal chemistry letters,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
July 1988,
Journal of medicinal chemistry,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
May 2000,
Journal of medicinal chemistry,
J Kitchin, and
A D Borthwick, and
A C Brodie, and
P C Cherry, and
A J Crame, and
A J Pipe, and
P A Procopiou, and
M A Seaman, and
J P Turnbull
June 1982,
Journal of medicinal chemistry,
