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Exposure to higher levels of fat in the diet increases the secretion of fat-digesting enzymes in pancreatic juice. This study examines the functional consequences of this phenomenon and demonstrates that adapting rats to high fat (triglyceride) loads increases the release of cholecystokinin (CCK) and the pancreatic secretory response to intraduodenal fat. Lipolytic activity in the small intestine was also higher in adapted rats. Exchanging pancreatic juice from unadapted rats with pancreatic juice from adapted rats decreased the response to fat in adapted rats and increased the response to fat in unadapted rats. Infusing oleic acid into unadapted rats stimulated CCK secretion and pancreatic exocrine secretion to levels observed with triglycerides in adapted rats. Pancreatic exocrine secretion in response to intraduodenal fat in rats adapted to a high-fat (20%) diet were significantly higher than the responses seen in rats fed a low-fat (5%) diet. Adaptation to fat increases the pancreatic secretory and plasma CCK responses to fat, apparently by increasing the efficiency of triglyceride digestion and thereby increasing CCK release.
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
January 1994,
JPEN. Journal of parenteral and enteral nutrition,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
September 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
January 1980,
The American journal of physiology,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
January 1991,
Digestion,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
July 1977,
Canadian journal of surgery. Journal canadien de chirurgie,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
January 1984,
JPEN. Journal of parenteral and enteral nutrition,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
March 1989,
International journal of pancreatology : official journal of the International Association of Pancreatology,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
May 1993,
Comparative biochemistry and physiology. Comparative physiology,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
November 1970,
The American journal of digestive diseases,
A W Spannagel, and
I Nakano, and
T Tawil, and
W Y Chey, and
R A Liddle, and
G M Green
January 1986,
Gastroenterologie clinique et biologique,
