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Fed and 24 h fasted rats were treated by stomach tube with different doses of either tolbutamide or gluypentide and they were compared with controls treated with placebo. At low doses glypentide was ten times more effective as hypoglycemic agent than tolbultamide whereas it was only twice as effective in the fasted rats. Supramaximal doses of either drug produced the same effect decreasing blood glucose levels. Both drugs were able to decrease the rise of blood ketones in fasted rats, but the comparative effect was not parallel to the one observed on glycemia and not proportional to the doses used. The different responses are interpreted as function of the hypoglycemic effect, which would be mainly mediated through the insulinotropic action of these drugs, while the hypoketonemic would be the result of both their insulinotropic effect and their direct action on lipolysis and ketogenesis.
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
March 1959,
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J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
January 1974,
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J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
July 1964,
Medical times,
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
July 1961,
Hospital (Rio de Janeiro, Brazil),
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
January 1986,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
January 1974,
Revista iberica de endocrinologia,
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
November 1963,
Zeitschrift fur Haut- und Geschlechtskrankheiten,
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
April 1964,
American journal of diseases of children (1960),
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
November 1956,
Metabolism: clinical and experimental,
J García-Rafanell, and
M A Lasunción, and
J Morell, and
E Herrera
June 1974,
Revista espanola de fisiologia,
