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We examined the effect of 7-nitro indazole (7-NI, 2.5-50 mg/kg, i.p.), an inhibitor of central nitric oxide (NO) synthesis, on general behaviour and sleep. The results show that 7-NI induces ptosis, a loss of the righting reflex and decrease of the EEG amplitudes. Furthermore, a duration of slow wave sleep (SWS) and REM sleep decreased, while the latencies of SWS and REM sleep increased. The effects of 7-NI on general behaviour and sleep were partially antagonized by intraventricular administration of the NO precursor, L-arginine (600 micrograms). These findings indicate that 7-NI induces a state of prominent central depression associated with motor deficit and decrease in sleep stages and wakefulness. It further suggests that NO exerts a significant excitatory effect on the neuronal structure involved in the regulation of locomotion and vigilance.
M R Dzoljic, and
R de Vries, and
R van Leeuwen
December 2000,
Acta crystallographica. Section C, Crystal structure communications,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
November 1996,
Neuroscience letters,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
October 1994,
Neuroreport,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
April 1995,
Neuroscience letters,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
September 1993,
British journal of pharmacology,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
January 1994,
Learning & memory (Cold Spring Harbor, N.Y.),
M R Dzoljic, and
R de Vries, and
R van Leeuwen
January 1995,
Life sciences,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
November 1994,
Neuropharmacology,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
November 2002,
Acta crystallographica. Section C, Crystal structure communications,
M R Dzoljic, and
R de Vries, and
R van Leeuwen
January 1996,
Learning & memory (Cold Spring Harbor, N.Y.),
