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We investigated the effect of gamma-interferon (gamma-IFN) on three cellular parameters: cell membrane fluidity and expression of two antigens that have been associated with cell proliferation, namely transferrin receptor (Tf-R: a cell surface protein) and Ki-67 antigen (Ki-67: a nuclear protein). We observed small, yet significant changes in the first two parameters, but not the third parameter. These were investigated in K562 cells, a human chronic myelocytic leukemia cell line. These results suggest that the microviscosity changes and the surface Tf-R density were closely associated, and that gamma-IFN was involved in increasing proliferative activity of the cells by decreasing membrane fluidity and upregulating Tf-R expression.
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
October 1985,
Cellular immunology,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
August 2022,
Cytokine,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
January 1993,
Archives of biochemistry and biophysics,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
January 1996,
Immunobiology,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
January 1994,
The Journal of international medical research,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
June 1987,
Behring Institute Mitteilungen,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
June 1986,
Cell structure and function,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
February 1996,
Journal of cellular physiology,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
December 1987,
The American journal of the medical sciences,
H Iwagaki, and
M Marutaka, and
T Yoshino, and
L Cao, and
I Sakuma, and
M Uomoto, and
Y Takeuchi, and
N Tanaka
February 1997,
Blood,
