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The effect of nickel (Ni) on the enzymatic activities in the pancreas of mice was studied. Administration of Ni at the dose of 5 mg Ni/kg increased the trypsin activity and decreased carboxypeptidase A activity, but did not affect the activities of chymotrypsin, carboxypeptidase B, amylase, and lipase. Increases in Ca concentrations in the pancreas after Ni administration were observed. In the pancreatic slice experiments, Ni treatment showed a slight decrease in trypsin activity and remarkable decreases in chymotrypsin and carboxypeptidase A activities, and Ca treatment induced increases in the activities of trypsin and carboxypeptidase A. These results suggest that the increase in trypsin activity in the pancreas after Ni administration results from the activation of trypsinogen by the Ca ion and that the decrease in carboxypeptidase A activity is based on the inhibitory effect of Ni on carboxypeptidase A activity.
T Funakoshi, and
K Kuromatsu, and
S Kojima
August 1971,
The American journal of pathology,
T Funakoshi, and
K Kuromatsu, and
S Kojima
January 1968,
Journal de physiologie,
T Funakoshi, and
K Kuromatsu, and
S Kojima
December 1962,
Gan,
T Funakoshi, and
K Kuromatsu, and
S Kojima
October 1975,
Minerva anestesiologica,
T Funakoshi, and
K Kuromatsu, and
S Kojima
April 1964,
Bollettino della Societa italiana di biologia sperimentale,
T Funakoshi, and
K Kuromatsu, and
S Kojima
January 1969,
Voprosy pitaniia,
T Funakoshi, and
K Kuromatsu, and
S Kojima
January 1963,
Archives des maladies professionnelles de medecine du travail et de securite sociale,
T Funakoshi, and
K Kuromatsu, and
S Kojima
January 1957,
Voprosy pitaniia,
T Funakoshi, and
K Kuromatsu, and
S Kojima
January 1953,
Annales de la nutrition et de l'alimentation,
T Funakoshi, and
K Kuromatsu, and
S Kojima
November 1961,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
