BIOMAT Database Logo BIOMAT Database Logo

CD4 deficiency in myelodysplastic syndrome with monosomy 7. 1996

C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Department of Paediatrics, University Hospital Nijmegen, Netherlands.

We describe a patient with myelodysplastic syndrome with monosomy 7 presenting with a T-cell defect. He suffered from infections from the age of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic syndrome at that time was thrombocytopenia with giant platelets. Monosomy 7 was found in the bone marrow cells. At the age of 11 years he developed other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed. CONCLUSIONS In non-HIV CD4 deficiency myelodysplastic syndrome has to be considered.

UI MeSH Term Description Entries
D008297 Male Males
D009006 Monosomy The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1. Monosomies
D009190 Myelodysplastic Syndromes Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA. Dysmyelopoietic Syndromes,Hematopoetic Myelodysplasia,Dysmyelopoietic Syndrome,Hematopoetic Myelodysplasias,Myelodysplasia, Hematopoetic,Myelodysplasias, Hematopoetic,Myelodysplastic Syndrome,Syndrome, Dysmyelopoietic,Syndrome, Myelodysplastic,Syndromes, Dysmyelopoietic,Syndromes, Myelodysplastic
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002897 Chromosomes, Human, Pair 7 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 7
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015704 CD4 Antigens 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120. Antigens, CD4,CD4 Molecule,CD4 Receptor,CD4 Receptors,Receptors, CD4,T4 Antigens, T-Cell,CD4 Antigen,Receptors, Surface CD4,Surface CD4 Receptor,Antigen, CD4,Antigens, T-Cell T4,CD4 Receptor, Surface,CD4 Receptors, Surface,Receptor, CD4,Surface CD4 Receptors,T-Cell T4 Antigens,T4 Antigens, T Cell
D016130 Immunophenotyping Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry. Lymphocyte Immunophenotyping,Lymphocyte Subtyping,Immunologic Subtyping,Immunologic Subtypings,Lymphocyte Phenotyping,Subtyping, Immunologic,Subtypings, Immunologic,Immunophenotyping, Lymphocyte,Immunophenotypings,Immunophenotypings, Lymphocyte,Lymphocyte Immunophenotypings,Lymphocyte Phenotypings,Lymphocyte Subtypings,Phenotyping, Lymphocyte,Phenotypings, Lymphocyte,Subtyping, Lymphocyte,Subtypings, Lymphocyte

Related Publications

C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
[Secondary myelodysplastic syndrome with monosomy 7].
May 1988, [Rinsho ketsueki] The Japanese journal of clinical hematology,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Sweet's syndrome associated with monosomy 7 myelodysplastic syndrome.
July 2001, European journal of internal medicine,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Spontaneous remission in monosomy 7 myelodysplastic syndrome.
April 1995, British journal of haematology,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Myelodysplastic syndrome with monosomy 7 and pulmonary aspergillosis.
June 2000, Singapore medical journal,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Myelodysplastic syndrome associated with monosomy 7 in a child with Bloom syndrome.
January 2000, Cancer genetics and cytogenetics,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Monosomy 7 in granulocytes and monocytes in myelodysplastic syndrome.
February 1987, The New England journal of medicine,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Myelodysplastic syndrome with monosomy 7 in adulthood: a distinct preleukaemic disorder.
January 1983, Haematologica,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
January 1999, Scandinavian journal of rheumatology,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Myelodysplastic syndrome associated with monosomy 7 in childhood: a retrospective study.
November 2006, Cancer genetics and cytogenetics,
C M Weemaes, and F Preijers, and G A de Vaan, and J A Bakkeren, and I S Klasen, and A Haraldsson
Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome.
August 2017, Leukemia,
Copied contents to your clipboard!