BIOMAT Database Logo BIOMAT Database Logo

Influence of the exercise protocol on hemodynamic, gas exchange, and neurohumoral responses to exercise in heart transplant recipients. 1996

L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Heart Transplant Unit, Rikshospitalet University Hospital, Oslo, Norway.

BACKGROUND A gradual accommodation to increasing exercise loads has been recommended for exercise testing in denervated posttransplantation heart recipients. However, how the exercise protocol influence the hemodynamic, gas exchange, and hormonal response to exercise in this not been studied. METHODS Nine heart transplant recipients tests incremental maximal bicycle ergometry tests in random order. Exercise stages of 1 and 3 minute durations were compared with matched work rate increments ranging between 30 and 40 W. Expiratory gas was measured continuously and arterial blood was sampled at each of the matched work rates. RESULTS Total exercise duration was 6.4 +/- and 15.3 +/- 0.7 minutes for the 1-minute and 3-minute protocols, respectively. Maximal workload was significantly higher during the 1-minute versus the 3-minute protocol (238 +/- 9 versus 200 +/- 11 W, p < 0.001), but maximal oxygen uptake was not significantly different (25.5 +/- 1.1 versus 26.5 +/- 1.2 ml. min-1.kg-1). Hemodynamic, metabolic, and some hormonal parameters showed marked differences between the two protocols, with significantly higher responses observed during the 3-minute protocol for heart rate, ventilation, lactate, atrial natriuretic factor, and growth hormone. Catecholamine (epinephrine and norepinephrine) and insulin responses did not differ between the two tests. If expressed as a relative exercise intensity (percentage of maximal oxygen uptake) no differences in hormonal responses were observed between the two protocols, except for growth hormone response which remained higher during the 3-minute protocol. CONCLUSIONS Although maximal oxygen uptake was independent of the exercise protocol in these heart transplant recipients, the exercise protocol has a major influence on the hormonal and metabolic response. The delayed response observed for oxygen uptake and hormonal responses suggests a significant physiologic lag time during the more rapidly incremental protocol. These differences should be taken into account when exercise is used as a method to evaluate the heart transplant recipient.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011659 Pulmonary Gas Exchange The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER. Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Gas exchange kinetics in heart transplant recipients.
May 1992, Chest,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Hemodynamic and neurohumoral responses to exercise in patients with congestive heart failure.
May 1993, Japanese circulation journal,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Gas exchange and cardiovascular kinetics with different exercise protocols in heart transplant recipients.
June 1997, Journal of applied physiology (Bethesda, Md. : 1985),
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Hemodynamic responses to upright exercise of adolescent cardiac transplant recipients.
August 1992, The Journal of pediatrics,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Gas exchange and metabolic transients in heart transplant recipients.
December 1988, Respiration physiology,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Physiological Responses to Exercise in Pediatric Heart Transplant Recipients.
May 2019, Medicine and science in sports and exercise,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Understanding exercise-induced hyperemia: central and peripheral hemodynamic responses to passive limb movement in heart transplant recipients.
November 2010, American journal of physiology. Heart and circulatory physiology,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Hemodynamic and neurohumoral responses to dynamic exercise: normal subjects versus patients with heart disease.
December 1987, Circulation,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Attenuated responses of Doppler-derived hemodynamic parameters during supine bicycle exercise in heart transplant recipients.
January 1999, Cardiology,
L Gullestad, and J Myers, and H Noddeland, and R Bjørnerheim, and O Djøseland, and C Hall, and O Gieran, and J Kjekshus, and S Simonsen
Cardiovascular responses of heart transplant recipients to graded exercise testing.
July 1992, Journal of applied physiology (Bethesda, Md. : 1985),
Copied contents to your clipboard!