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Five antibodies that stained renin in the kidney were used to investigate the presence of renin in human placenta and fetal membranes. Despite a large number of experimental approaches to enhance penetration of the immunoglobulins, only two of them showed immunostaining in placenta and fetal membranes. Staining was found in placental syncytiotrophoblast, the amnionic epithelium overlying the placenta, and in glandular epithelial cells present in the decidua adhering to the fetal membranes. It was most consistent, however, in a small infiltrating cell type dispersed through the fetoplacental layers. The two antibodies that revealed immunostaining in all preparations showed high affinity cross-reactivity with cathepsin D. Among other, less plausible, explanations, this raises the possibility that the bulk of 'renin' found in placenta and fetal membranes is not identical to renal renin, but may be cathepsin D or a substance related to both cathepsin D and renin.
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
June 1984,
Toxicology and applied pharmacology,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
October 1996,
The Journal of clinical endocrinology and metabolism,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
January 1978,
Prostaglandins,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
March 1967,
Obstetrics and gynecology,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
December 2005,
Cellular and molecular biology (Noisy-le-Grand, France),
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
April 1993,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
June 1989,
Neurochemical research,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
December 1991,
The Journal of endocrinology,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
October 1982,
Journal of steroid biochemistry,
M Hanssens, and
L Vercruysse, and
L Verbist, and
R Pijnenborg, and
M J Keirse, and
F A Van Assche
February 1994,
Histochemistry,
