BIOMAT Database Logo BIOMAT Database Logo

Neutralization of bee venom lethality by immune serum antibodies. 1996

M J Schumacher, and N B Egen, and D Tanner
Steele Memorial Children's Research Center, University of Arizona, Tucson, USA.

The lethal effects of Africanized honey bee venom depend on the absorption of venom delivered during simultaneous sting attacks by large numbers of bees. The hypothesis that antibodies to whole bee venom and bee venom components could neutralize the lethal effect of bee venom was tested. Antibodies from beekeepers and immunized rabbits were incubated with bee venom and neutralization was studied by survival of intravenously injected mice. Beekeeper serum antibodies were found effective in protecting mice challenged with whole venom, and serum from rabbits immunized with phospholipase A2 (PLA2) was effective in protection against lethal effects of PLA2. Serum antibodies from rabbits immunized with whole venom or melittin were ineffective in neutralizing whole venom in vivo and had low titers in a venom enzyme-linked immunosorbent assay. The results suggest the need for development of more effective methods for raising antitoxic antibodies to bee venom components in other animals as a means of developing an antiserum that would be effective for treatment of human victims of multiple bee stings.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007106 Immune Sera Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen. Antisera,Immune Serums,Sera, Immune,Serums, Immune
D007299 Insect Bites and Stings Bites and stings inflicted by insects. Insect Bites,Insect Stings,Bite, Insect,Bites, Insect,Insect Bite,Insect Sting,Sting, Insect,Stings, Insect
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D008555 Melitten Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes. Melittin,Mellitin
D010741 Phospholipases A Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D004306 Dose-Response Relationship, Immunologic A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

M J Schumacher, and N B Egen, and D Tanner
In vivo neutralization of bee venom lethality by IgY antibodies.
July 2021, Molecular immunology,
M J Schumacher, and N B Egen, and D Tanner
Neutralization of Apis mellifera bee venom activities by suramin.
June 2013, Toxicon : official journal of the International Society on Toxinology,
M J Schumacher, and N B Egen, and D Tanner
Venom neutralization by rattlesnake serum albumin.
June 1969, Science (New York, N.Y.),
M J Schumacher, and N B Egen, and D Tanner
Potentiation of bleomycin lethality in HeLa and V79 cells by bee venom.
September 2009, Arhiv za higijenu rada i toksikologiju,
M J Schumacher, and N B Egen, and D Tanner
Neutralization of pit viper venom by king snake serum.
July 1950, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M J Schumacher, and N B Egen, and D Tanner
Lethality and histopathological alterations caused by Phoneutria nigriventer spider venom from Argentina: Neutralization of lethality by experimental and therapeutic antivenoms.
January 2017, Toxicon : official journal of the International Society on Toxinology,
M J Schumacher, and N B Egen, and D Tanner
Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum.
January 1990, Infection and immunity,
M J Schumacher, and N B Egen, and D Tanner
[Radioprotection by bee venom].
March 1970, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
M J Schumacher, and N B Egen, and D Tanner
Neutralization of HIV infection by serum IgA antibodies.
January 1995, Advances in experimental medicine and biology,
M J Schumacher, and N B Egen, and D Tanner
IgE antibodies to bee venom, phospholipase A, melittin and wasp venom.
September 1979, Clinical allergy,
Copied contents to your clipboard!