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To determine whether the FHIT gene at 3p14.2 is altered in head and neck squamous cell carcinomas (HNSCC), we examined 26 HNSCC cell lines for deletions within the FHIT locus by Southern analysis, for allelic losses of specific exons FHIT by fluorescence in situ hybridization (FISH) and for integrity of FHIT transcripts. Three cell lines exhibited homozygous deletions within the FHIT gene, 55% (15/25) showed the presence of aberrant transcripts, and 65% (13/20) showed the presence of multiple cell populations with losses of different portions of FHIT alleles by FISH of FHIT genomic clones to interphase nuclei. When the data obtained by FISH and by reverse transcriptase-PCR analyses are combined, 22 of 26 cell lines showed alterations of at least one allele of the FHIT gene. Our data indicate that the FHIT gene is disrupted in HNSCCs and hence, loss of FHIT function may be important in the development and/or progression of head and neck cancers.
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
July 1999,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
July 1998,
Oncogene,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
April 2022,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
August 2011,
Anti-cancer drugs,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
October 2000,
The Journal of laryngology and otology,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
June 2007,
Annals of oncology : official journal of the European Society for Medical Oncology,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
July 1996,
The Annals of otology, rhinology, and laryngology,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
November 2021,
Clinical and translational medicine,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
April 2023,
Heliyon,
L Virgilio, and
M Shuster, and
S M Gollin, and
M L Veronese, and
M Ohta, and
K Huebner, and
C M Croce
January 2017,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
