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Design of specific peptide structures and subtilisin enzyme inhibitors using alpha,beta-dehydro-residues. 1996

T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

UI MeSH Term Description Entries
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D013381 Subtilisins A family of SERINE ENDOPEPTIDASES isolated from Bacillus subtilis. EC 3.4.21.- Alcalase,AprA-Subtilisin,Bacillus amyloliquefaciens Serine Protease,Bacillus subtilis Alkaline Proteinase,Carlsberg Subtilisin,Maxatase,Nagarse,Novo Alcalase,Profezim,Protease VII,Subtilisin 72,Subtilisin A,Subtilisin BPN',Subtilisin Carlsberg,Subtilisin DY,Subtilisin E,Subtilisin GX,Subtilisin Novo,Subtilopeptidase A,Alcalase, Novo,AprA Subtilisin,Subtilisin, Carlsberg
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D015195 Drug Design The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis. Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D015202 Protein Engineering Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes. Genetic Engineering of Proteins,Genetic Engineering, Protein,Proteins, Genetic Engineering,Engineering, Protein,Engineering, Protein Genetic,Protein Genetic Engineering
D017433 Protein Structure, Secondary The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to ALPHA-HELICES; BETA-STRANDS (which align to form BETA-SHEETS), or other types of coils. This is the first folding level of protein conformation. Secondary Protein Structure,Protein Structures, Secondary,Secondary Protein Structures,Structure, Secondary Protein,Structures, Secondary Protein

Related Publications

T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
Alpha,beta-dehydro residues in the design of peptide and protein structures.
August 1990, Acta crystallographica. Section B, Structural science,
T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
Alpha-beta-dehydro-amino acid residues in the design of peptide structures. Molecular and crystal structures of two folded dehydro peptides.
February 1992, International journal of biological macromolecules,
T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
The design of an inhibitor using alpha, beta-dehydro residues.
August 1996, Journal of biomolecular structure & dynamics,
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Peptide design using alpha,beta-dehydro amino acids: from beta-turns to helical hairpins.
January 2004, Biopolymers,
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Conformation and design of peptides with alpha,beta-dehydro-amino acid residues.
January 1996, Progress in biophysics and molecular biology,
T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
alpha,beta-Dehydro-amino acid residues in the design of peptide structures: synthesis, crystal structure, and molecular conformation of two homologous peptides-N-Ac-dehydro-Phe-L-Leu-OCH3 and N-Ac-dehydro-Phe-NorVal-OCH3.
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T P Singh, and B Padmanabhan, and P Narula, and A K Saxena, and C Betzel, and P Sharma, and S Dey
A peptide inhibitor of HIV-1 protease using alpha, beta- dehydro residues: a structure based computer model.
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A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model.
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A proteinase K inhibitor using alpha,beta-unsaturated (dehydro) residues: a presumptive model.
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Design of peptides with alpha,beta-dehydro residues: a dipeptide with a branched beta-carbon dehydro residue at the (i+1) position, methyl N-(benzyloxycarbonyl)-alpha,beta-didehydrovalyl-L-tryptophanate.
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