Protective effects of antithrombin III supplementation on warm ischemia and reperfusion injury in rat liver. 1996

K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
First Department of Surgery, Kagawa Medical School, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-07, Japan.

The effect of antithrombin III (AT III) supplementation on energy status, microcirculation, cytoprotection, and prostacyclin (PGI2) production during and after a period of warm ischemia of the rat liver was investigated. AT III supplementation (250 units/kg) stimulate prostaglandin I2 (PGI2) production from 1 hour after administration, with maximal production observed at 3 hours. Ischemia was induced by occluding the hepatoduodenal ligament for 30 minutes, and experiments were continued for 60 minutes after reperfusion. The rats received AT III (250 units/kg IC) 30 minutes before induction of liver ischemia (AT III group). In the AT III group, recovery of the beta-ATP/inorganic phosphate ratio measured by 31P nuclear magnetic resonance showed significant improvement (p < 0.01), and the recovery of tissue blood flow markedly improved (p < 0.01) compared to the saline-treated group (control group). Leakages of aspartame aminotransferase, alanine aminotransferase, and lactate dehydrogenase were mitigated in the AT III group (p < 0. 05). Ultrastructural alterations of sinusoidal endothelial cells were markedly reduced in the AT III group. The PGI2 level at the end of reperfusion was significantly elevated (p < 0.01) in the AT III group compared to the control group. The results of this study indicated that pretreatment with AT III significantly improved the energy status and microcirculation, as well as histologic damage, after liver ischemia and reperfusion. One of the fundamental effects of AT III might be mediated through the production of prostacyclin.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D007770 L-Lactate Dehydrogenase A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist. Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008102 Liver Circulation The circulation of BLOOD through the LIVER. Hepatic Circulation,Circulation, Liver,Circulation, Hepatic
D008297 Male Males
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D011464 Epoprostenol A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). Prostacyclin,Prostaglandin I2,Epoprostanol,Epoprostenol Sodium,Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer,Flolan,Prostaglandin I(2),Veletri
D001783 Blood Flow Velocity A value equal to the total volume flow divided by the cross-sectional area of the vascular bed. Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D000255 Adenosine Triphosphate An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2

Related Publications

K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
October 2006, Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
March 2010, American journal of surgery,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
September 2011, Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
March 1999, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
January 2005, European journal of ophthalmology,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
January 2005, European journal of ophthalmology,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
February 2004, Chinese medical journal,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
July 2013, Phytomedicine : international journal of phytotherapy and phytopharmacology,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
December 1993, Nihon Geka Gakkai zasshi,
K Okano, and Y Kokudo, and K Okajima, and M A Hossain, and K Ishimura, and S Yachida, and T Tsubouchi, and H Wakabayashi, and T Maeba, and H Maeta
December 2010, Journal of natural products,
Copied contents to your clipboard!