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The role of nitric oxide in the regulation of adrenal steroidogenesis was examined in BALB/c mice by employing the nitric oxide synthase inhibitors NG-nitro L-arginine methyl ester (L-NAME) and NG-nitro L-arginine (L-NNA). The administration of a single dose of nitric oxide inhibitors (50 mg kg-1 body wt. i.p.) induced a fourfold increase in plasma corticosterone. Treatment with L-arginine (750 mg kg-1 body wt. s.c.), but not D-arginine, completely prevented corticosterone increases induced by L-NAME. To analyse whether the activation of adrenal steroidogenesis induced by nitric oxide synthase inhibitors involved the stimulation of the hypothalamo-pituitary-adrenal axis. ACTH levels were assessed. It was found that L-NAME significantly enhanced plasma ACTH concentrations. Genetic variations in this regulatory pathway are suggested by the fact that L-NAME increased corticosterone levels in BALB/c. C3H/He and DBA-2 mice, but not in C57BI/c mice, a strain characterized by a low steroid response to stress.
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 2000,
Methods in molecular medicine,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
September 1997,
Acta anaesthesiologica Sinica,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 1997,
Polish journal of pharmacology,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
November 1997,
Arteriosclerosis, thrombosis, and vascular biology,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 2010,
Pharmaceuticals (Basel, Switzerland),
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 2005,
Current topics in medicinal chemistry,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 1996,
Methods in enzymology,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 2011,
Acta neurochirurgica. Supplement,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
June 1999,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
M Giordano, and
M Vermeulen, and
A S Trevani, and
G Dran, and
G Andonegui, and
J R Geffner
January 1987,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
