Nicotine gum dose and weight gain after smoking cessation. 1996

K Doherty, and F S Militello, and T Kinnunen, and A J Garvey
School of Dental Medicine, Harvard University, Boston, Massachusetts, USA.

The authors examined weight gain in 79 abstinent cigarette smokers during treatment with placebo or with 2 mg or 4 mg of nicotine gum. Results indicated that nicotine gum suppressed weight gain in a linear fashion with increasing nicotine dose. At 90 days postcessation, placebo gum users gained 3.7 kg, 2-mg gum users gained 2.1 kg, and 4-mg gum users gained 1.7 kg. Assessment of nicotine replacement by means of pre- and postcessation salivary continue levels revealed that smokers who replaced a greater percentage of their baseline continue levels during treatment gained less weight. Percentage of baseline cotinine replaced remained related to weight gain after the number of pieces of gum used was controlled. Implications for smokers hoping to minimize postcessation weight gain are discussed.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009538 Nicotine Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine Bitartrate,Nicotine Tartrate
D010947 Plants, Toxic Plants or plant parts which are harmful to man or other animals. Plants, Poisonous,Plant, Poisonous,Plant, Toxic,Poisonous Plant,Poisonous Plants,Toxic Plant,Toxic Plants
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D002638 Chewing Gum A preparation of chicle, sometimes mixed with other plastic substances, sweetened and flavored. It is masticated usually for pleasure as a candy substitute but it sometimes acts as a vehicle for the administration of medication. Chewing Gums,Gum, Chewing,Gums, Chewing
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014030 Tobacco, Smokeless Any product of NICOTIANA TABACUM that is not smoked but is either inhaled through the nose, chewed, or stored in cheek pouches. Chewing Tobacco,Oral Tobacco,Smokeless Tobacco,Snuff,Dipping Tobacco,Gutka,Gutka Tobacco,Mint Snuff,Snus,Chewing Tobaccos,Dipping Tobaccos,Gutka Tobaccos,Gutkas,Snuff, Mint,Tobacco, Chewing,Tobacco, Dipping,Tobacco, Gutka,Tobacco, Oral,Tobaccos, Chewing,Tobaccos, Dipping,Tobaccos, Gutka,Tobaccos, Smokeless

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