BIOMAT Database Logo BIOMAT Database Logo

p53 protein expression in laryngeal squamous cell carcinomas bearing wild-type and mutated p53 gene. 1996

G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
II Servizio di Anatomia Patologica, Università di Milano, Ospedale Maggiore, Italy.

We performed an immunohistochemical analysis to investigate the expression of p53 protein in a panel of 18 laryngeal squamous cell carcinomas, 15 primary tumours and three in relapse, previously analysed by us for the presence of p53 gene mutations. Dysplastic and/or normal surrounding mucosa was evaluated in 15 different tumours. The results of our study are the following: (1) expression of p53 protein was observed in one out of five tumours positive for p53 gene mutations (20%) and in 10 out of 13 (80%) negative cases; (2), p53 protein over-expression was frequently observed in normal and/or dysplastic mucosa surrounding either wild-type (7/11) or mutated p53 tumours (2/4); (3), p53 immunoreactive cells showed a pattern of distribution in normal and mildly/ moderately dysplastic mucosa (basal layers), different from that in severely dysplastic mucosa (whole thickness). These data further support the hypothesis that p53 protein over-expression may be a marker of the earliest phases of multistep tumorigenesis in laryngeal squamous cell carcinoma.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007822 Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS. Cancer of Larynx,Laryngeal Cancer,Larynx Neoplasms,Cancer of the Larynx,Larynx Cancer,Neoplasms, Laryngeal,Cancer, Laryngeal,Cancer, Larynx,Cancers, Laryngeal,Cancers, Larynx,Laryngeal Cancers,Laryngeal Neoplasm,Larynx Cancers,Larynx Neoplasm,Neoplasm, Laryngeal,Neoplasm, Larynx,Neoplasms, Larynx
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D001706 Biopsy Removal and pathologic examination of specimens from the living body. Biopsies

Related Publications

G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
[Expression of Ki-67 and p53 in laryngeal squamous cell carcinomas].
January 2005, Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53.
February 2004, Cancer letters,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53.
May 2000, Cancer gene therapy,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Over-expression of tumour suppressor gene p53 in laryngeal squamous cell carcinomas and its prognostic significance.
February 1995, Clinical otolaryngology and allied sciences,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Correlation between p53 gene mutation, p53 protein labeling and PCNA expression in oral squamous cell carcinomas.
January 1998, Anticancer research,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma.
April 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Refined characterization of head and neck squamous cell carcinomas expressing a seemingly wild-type p53 protein.
January 2006, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Prognostic significance of p63, p53 and ki67 expression in laryngeal basaloid squamous cell carcinomas.
January 2011, B-ENT,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene.
March 2003, Journal of radiation research,
G Pruneri, and L Pignataro, and N S Fracchiolla, and S Ferrero, and P Capaccio, and N Carboni, and A Ottaviani, and A T Maiolo, and A Neri, and R Buffa
NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas.
March 2006, Diagnostic molecular pathology : the American journal of surgical pathology, part B,
Copied contents to your clipboard!