[Long-term clozapine treatment of schizophrenic type psychoses and the significance of side-effects (author's transl)].
1977
M Zapletálek, and
O Preiningerová, and
S Pazdirek, and
H Hanus, and
P Stránský
UI
MeSH Term
Description
Entries
D008297
Male
Males
D003024
Clozapine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Clozaril,Leponex
D003984
Dibenzazepines
Compounds with two BENZENE rings fused to AZEPINES.
D004569
Electroencephalography
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
EEG,Electroencephalogram,Electroencephalograms
D005260
Female
Females
D006801
Humans
Members of the species Homo sapiens.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328
Adult
A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.
Adults
D012559
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.