-transparent.png){kind=logo}
We describe a novel genetic locus, wunen (wun), required for guidance of germ cell migration in early Drosophila development. Loss of wun function does not abolish movement but disrupts the orientation of the motion causing the germ cells to disperse even though their normal target, the somatic gonad, is well formed. We demonstrate that the product of this gene enables a signal to pass from the soma to the germ line and propose that the function of this signal is to selectively stabilize certain cytoplasmic extensions resulting in oriented movement. To characterize this guidance factor, we have mapped wun to within 100 kb of cloned DNA.
Related Publications
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
November 2005,
The Journal of cell biology,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
September 2001,
Proceedings of the National Academy of Sciences of the United States of America,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
September 2002,
Genetics,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
February 1977,
Nature,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
January 1994,
Development (Cambridge, England),
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
July 1987,
Genetics,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
October 2008,
The Journal of cell biology,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
January 1997,
Cold Spring Harbor symposia on quantitative biology,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
June 1990,
Genetics,
N Zhang, and
J Zhang, and
Y Cheng, and
K Howard
January 1987,
NCI monographs : a publication of the National Cancer Institute,
