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Bordetella pertussis produces a catalase and a Fe-superoxide dismutase. The importance of these enzymes in virulence was investigated, in vitro as well as in vivo, by using mutants deficient in their production. The catalase-deficient mutant survived within polymorphonuclear leukocytes, killed J774A.1 macrophages through apoptosis, and behaved as the parental strain in a murine respiratory infection model. These results suggest no direct role for catalase in B. pertussis virulence. The absence of expression of Fe-superoxide dismutase had profound effects on the bacterium including a reduced ability to express adenylate cyclase-hemolysin and pertactin, two factors important for B. pertussis pathogenesis. The Fe-superoxide dismutase-deficient mutant also had decreased abilities to colonize and persist in the murine respiratory infection model.
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
March 1990,
Infection and immunity,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
April 1997,
Journal of bacteriology,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
January 2022,
Free radical research,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
November 1985,
Canadian journal of microbiology,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
February 1993,
Carcinogenesis,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
April 1982,
FEBS letters,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
April 1986,
Molecular and biochemical parasitology,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
May 1983,
The Journal of biological chemistry,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
November 2016,
Microbiology and immunology,
N Khelef, and
D DeShazer, and
R L Friedman, and
N Guiso
October 1992,
Free radical biology & medicine,
