-transparent.png){kind=logo}
Structure and chromosomal localization of the human homeobox gene Prox 1. 1996
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
The genomic organization and nucleotide sequence of the human homeobox gene Prox 1 as well as its chromosomal localization have been determined. This gene spans more than 40 kb, consists of at least 5 exons, and encodes an 83-kDa protein. It shows 89% identity with the chicken sequence at the nucleotide level in the coding region, while the human and chicken proteins are 94% identical. Among the embryonic tissues analyzed (lens, brain, lung, liver, and kidney), the human Prox 1 gene is most actively expressed in the developing lens, similar to the expression pattern of the chicken Prox 1 gene. The Prox 1 gene was mapped to human chromosome 1q32.2-q32.3.
Related Publications
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
December 2000,
Gene,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
April 1998,
Genomics,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
May 1995,
Genomics,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
May 2000,
Gene,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
October 1994,
Genomics,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
August 1998,
Mechanisms of development,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
January 1998,
Mammalian genome : official journal of the International Mammalian Genome Society,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
September 1996,
Genomics,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
October 1999,
Mammalian genome : official journal of the International Mammalian Genome Society,
R D Zinovieva, and
M K Duncan, and
T R Johnson, and
R Torres, and
M H Polymeropoulos, and
S I Tomarev
June 1994,
Journal of immunology (Baltimore, Md. : 1950),
