-transparent.png){kind=logo}
The rat 5-HT1B receptor (also referred to as the 5-HT1D beta receptor) is expressed in both serotonergic and nonserotonergic neurons in the rat brain, where it has been hypothesized to inhibit the release of neurotransmitters from axonal terminals. In this study we investigated the effect of chemical axotomy of serotonergic processes by 5,7-dihydroxytryptamine on the levels of 5-HT1B mRNA in the dorsal raphe nucleus and several postsynaptic brain areas using in situ hybridization. 5,7-dihydroxytryptamine (i.c.v.) reduced forebrain ([3H]citalopram binding to serotonin transporter by 62-96% whereas binding in the dorsal raphe nucleus was preserved. Serotonin transporter mRNA hybridization signal in the dorsal raphe nucleus was only slightly reduced after 5,7-dihydroxytryptamine. These results suggest that our lesioning protocol caused axonal degeneration with preservation of most of the serotonergic perikarya in the dorsal raphe nucleus. 5-HT1B mRNA hybridization signal in postsynaptic regions was unchanged by serotonergic lesions, but was markedly reduced in the dorsal raphe nucleus. Thus, disruption of serotonergic innervation affects the regulation of presynaptic and postsynaptic 5-HT1B mRNA differently. Furthermore, although both 5-HT1B receptor and serotonin transporters are found in serotonergic terminals, their levels may be regulated differentially during the period of regrowth that follows chemical axotomy.
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
August 2006,
Behavioural brain research,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
June 1988,
Japanese journal of pharmacology,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
April 1995,
Neuroreport,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
April 2005,
Synapse (New York, N.Y.),
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
July 1998,
The Journal of physiology,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
June 2006,
Brain research bulletin,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
November 1999,
Molecular psychiatry,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
July 1997,
Journal of receptor and signal transduction research,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
March 1996,
Brain research. Molecular brain research,
J F Neumaier, and
P Szot, and
E R Peskind, and
D M Dorsa, and
M W Hamblin
January 2017,
Frontiers in cellular neuroscience,
