-transparent.png){kind=logo}
Bifemelane hydrochloride (BF) is a modulator of various neurotransmitter systems. The effect of BF on the cholinergic system was studied in the gerbil hippocampus at 100 days after ischemic damage. Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. Muscarinic receptor density was markedly decreased in the CA1 subfield after ischemia. Interestingly, BF-treated animals showed higher muscarinic receptor binding in many brain areas, particularly in the dentate gyrus. These results indicate that BF modulates cholinergic neuronal plasticity in the ischemic hippocampus after long-term survival.
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
September 1992,
Brain research,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
January 1996,
Life sciences,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
January 1993,
Life sciences,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
January 1992,
Archives internationales de pharmacodynamie et de therapie,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
February 1986,
No to shinkei = Brain and nerve,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
June 2017,
Molecular medicine reports,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
January 1990,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
October 1992,
Neuroscience letters,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
September 1989,
Journal of the neurological sciences,
Y L Huang, and
H Onodera, and
A Takeda, and
Y Itoyama, and
K Kogure
September 1994,
No to shinkei = Brain and nerve,
