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BACKGROUND Depression is associated with alterations in behavior and neuroendocrine systems that are risk factors for decreased bone mineral density. This study was undertaken to determine whether women with past or current major depression have demonstrable decreases in bone density. METHODS We measured bone mineral density at the hip, spine, and radius in 24 women with past or current major depression and 24 normal women matched for age, body-mass index, menopausal status, and race, using dual-energy x-ray absorptiometry. We also evaluated cortisol and growth hormone secretion, bone metabolism, and vitamin D-receptor alleles. RESULTS As compared with the normal women, the mean (+/-SD) bone density in the women with past or current depression was 6.5 percent lower at the spine (1.00+/-0.15 vs. 1.07+/-0.09 g per square centimeter, P=0.02), 13.6 percent lower at the femoral neck (0.76+/-0.11 vs. 0.88+/-0.11 g per square centimeter, P<0.001), 13.6 percent lower at Ward's triangle (0.70+/-0.14 vs. 0.81+/-0.13 g per square centimeter, P<0.001), and 10.8 percent lower at the trochanter (0.66+/-0.11 vs. 0.74+/-0.08 g per square centimeter, P<0.001). In addition, women with past or current depression had higher urinary cortisol excretion (71+/-29 vs. 51+/-19 micrograms per day [196+/-80 vs. 141+/-52 nmol per day], P=0.006), lower serum osteocalcin concentration (P=0.04), and lower urinary excretion of deoxypyridinoline (P=0.02). CONCLUSIONS Past or current depression in women is associated with decreased bone mineral density.
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
December 2005,
Joint bone spine,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
February 2002,
Yonsei medical journal,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
January 1999,
Journal of psychosomatic research,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
January 2013,
Archives of osteoporosis,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
September 2013,
Internal and emergency medicine,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
April 2020,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
January 2004,
Journal of bone and mineral metabolism,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
March 2008,
Bone,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
September 2012,
Korean journal of women health nursing,
D Michelson, and
C Stratakis, and
L Hill, and
J Reynolds, and
E Galliven, and
G Chrousos, and
P Gold
April 2000,
The Journal of rheumatology,
