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An original route of prostaglandin F2alpha administration for uterine evacuation in a case of a midtrimester intrauterine death is presented. The ultrasonographic study revealed a hydropic fetus with a massive nuchal cystic hygroma and oligohydramnios. Given our previous experience with intrafetal prostaglandin administration in a similar case but with a living fetus, we injected prostaglandin F2alpha into the nuchal cysts under continuous ultrasonographic guidance in order to induce uterine evacuation. The pregnancy was successfully terminated 16 h later.
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