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Pinusolide, a potent platelet activating factor (PAF) receptor binding antagonist, inhibited PAF-induced aggregation of rabbit platelets with an IC50 value of 5 microM, whereas no inhibitory effects on the aggregation induced by ADP, thrombin, and collagen were observed. Pinusolide protected the mice from PAF-induced lethality with ED50 values of 1.1 mg/kg, i.v. and 69 mg/kg, p.o. Topically given pinusolide at 2 mg/ear effectively inhibited croton oil induced mouse ear edema. All the pinusolide treated ears recovered to normal healthy appearance in a sharp contrast to totally necrotized untreated ears. These results indicated that pinusolide is a potent and specific PAF antagonist in all experimental models as shown in vitro, in vivo, and in animal tests.
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
February 1999,
Planta medica,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
November 1990,
Arzneimittel-Forschung,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
December 1991,
Arzneimittel-Forschung,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
December 1991,
Lipids,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
June 1987,
The Journal of pharmacology and experimental therapeutics,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
January 1990,
Archives internationales de pharmacodynamie et de therapie,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
November 1988,
The Journal of pharmacology and experimental therapeutics,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
April 1987,
Immunopharmacology,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
July 1991,
British journal of pharmacology,
H O Yang, and
Y H Kang, and
D Y Suh, and
Y C Kim, and
B H Han
December 1990,
Prostaglandins,
