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Twenty days after the onset of alloxan-induced diabetes, a villous hyperplasia has developed in the intestines of rats having free access to food. The transformation is characterised by a considerable increase in the area of the villous surface, caused by an enhanced mitotic activity in the crypts. The absorption of glucose or methionine by jejunal loops, whether expressed in terms of serosal area or villous area, is unchanged at this stage. On the other hand, the specific activity of certain disaccharidases and dipeptidases in crude mucosal homogenates is greater in diabetic animals, but quantitative histochemistry revealed no changes in the activities of alkaline phosphatase, leucine amino-peptidase and non-specific esterase in the individual enterocytes. Thus the biochemical changes may simply reflect the hyperplasia of the mucosa. The blood sugar level does not appear to be directly responsible for the mucosal transformation; however, the positive correlation between the daily food intake and the villus height suggests a role of hyperphagia and consequent increased luminal nutrition in the development of the hyperplasia.
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
January 1982,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
February 1979,
Clinical science (London, England : 1979),
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
December 1976,
Revista espanola de las enfermedades del aparato digestivo,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
February 1970,
Biochimica et biophysica acta,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
January 1976,
Indian journal of medical sciences,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
June 2001,
Microscopy research and technique,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
January 1991,
Journal of gastroenterology and hepatology,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
November 1957,
Biulleten' eksperimental'noi biologii i meditsiny,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
January 1974,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
H Lorenz-Meyer, and
F Thiel, and
H Menge, and
H Gottesbüren, and
E O Riecken
July 1979,
Gastroenterology,
