Biomaterial Database

[Investigations of alpha-1-antitrypsin level in blood serum of patients with melanoma of the choroid]. 1995

A Matysik, and B Jakubowska-Solarska, and J Toczołowski

Z II Kliniki Okulistyki AM w Lublinie.

OBJECTIVE To assess alpha-1-antitrypsin concentration in blood serum of patients with melanoma of the choroid. METHODS 35 patients (14 women and 21 men) were examined. The control group comprised 12 healthy persons. Tests of alpha-1-antitrypsin level were performed using immunologicresponse produced by diagnostic antibodies with the antigen present in the studied seru. Behring Nor-Partigen platelets were used for determinations. The results were statistically analysed using Cohran-Cox test. RESULTS The investigations have shown, in patients with melanoma of the choroid, the level of alpha-1-antitrypsin amounts, on the average, to 296 75.5 mg/dl. In the control group, however, it was 219 50.1 mg/dl. The statistical significance was p < 0.001. CONCLUSIONS A considerably higher level of glycoprotein in patients with melanoma of the choroid suggests the usefulness of determining alpha-1-antitrypsinlevel on recognising neoplasms of the visual system.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008545	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002830	Choroid Neoplasms	Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).	Choroidal Neoplasms,Choroid Neoplasm,Choroidal Neoplasm,Neoplasm, Choroid,Neoplasm, Choroidal,Neoplasms, Choroid,Neoplasms, Choroidal
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000515	alpha 1-Antitrypsin	Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.	Trypsin Inhibitor, alpha 1-Antitrypsin,alpha 1-Protease Inhibitor,alpha 1-Proteinase Inhibitor,A1PI,Prolastin,Serpin A1,Zemaira,alpha 1 Antiprotease,alpha 1-Antiproteinase,1-Antiproteinase, alpha,Antiprotease, alpha 1,Inhibitor, alpha 1-Protease,Inhibitor, alpha 1-Proteinase,Trypsin Inhibitor, alpha 1 Antitrypsin,alpha 1 Antiproteinase,alpha 1 Antitrypsin,alpha 1 Protease Inhibitor,alpha 1 Proteinase Inhibitor