-transparent.png){kind=logo}
Immunotoxins were constructed by linking immunoglobulins specific for murine cytomegalovirus (MCMV) to deglycosylated ricin A chain. Toxicities toward MCMV-infected and uninfected cells were determined by measuring the inhibition of protein synthesis following a 48-h exposure to immunotoxins commencing 24 h after infection. The 50% inhibitory concentrations ranged from 0.4 to 4 micrograms/ml for infected cells and from 22 to 120 micrograms/ml for uninfected cells. Selectivity indices ranged from 30 to 157. Control immunotoxins, which were constructed identically except that the immunoglobulin moiety had no specificity toward MCMV antigens, had 50% inhibitory concentrations of 50 and 100 micrograms/ml toward infected and uninfected cells, respectively.
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
May 1994,
Chinese medical journal,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
November 1988,
British journal of haematology,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
October 1983,
Proceedings of the National Academy of Sciences of the United States of America,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
September 1987,
Immunopharmacology,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
February 1991,
Seminars in cell biology,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
October 1986,
Cellular immunology,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
June 1993,
Experimental cell research,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
January 1982,
Immunological reviews,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
January 1985,
Molekuliarnaia biologiia,
B B Barnett, and
D F Smee, and
S M Malek, and
R W Sidwell
January 2017,
Journal of immunology research,
