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The present study was carried out to clarify the mechanism of histamine-induced gastric mucosal damage in rats. Following an injection of histamine (80 mg/kg), pH dropped within 30 min. and then recovered control value (pH = 4-5) 4 hr later. The decrease in mucosal mucin content and the appearance of haemorrhagic erosions followed the drop in pH. The recovery of mucosal mucin content preceded the healing of haemorrhagic erosions and pH recovery to the control level. Histamine also caused qualitative changes in corpus mucins. These qualitative changes induced by histamine were eliminated at 7 hr following the administration of histamine. It appears from the present results that increase in HCl and decrease in mucins induced by histamine bring about gastric damage.
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Digestive diseases and sciences,
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April 1981,
Agents and actions,
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May 2000,
Life sciences,
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K Hotta
November 1978,
Gastroenterology,
S Ohara, and
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K Hotta
March 1978,
Gastroenterology,
S Ohara, and
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K Hotta
January 1983,
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S Ohara, and
M Tsurui, and
T Watanabe, and
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K Hotta
June 1980,
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M Tsurui, and
T Watanabe, and
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January 1985,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Ohara, and
M Tsurui, and
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February 1995,
The Journal of pharmacy and pharmacology,
S Ohara, and
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K Hotta
May 2013,
Histochemistry and cell biology,
