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The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y. pestis EV) located inside the cells was studied. Peritoneal macrophages of albino mice with aceptic inflammation of the abdominal cavity caused by intraperitoneal administration of 2 ml of sterile meat-peptone broth were used in the experiments. The ratio of the macrophages and microbes was 1 : 50. A part of the mice were treated with prodigiozan 24 hours before taking the exudate. The preparations of the macrophages of albino mice with the microbes absorbed by them served as the control. The effect of the antibiotics and their combinations with prodigiozan was stimated by the coefficient of multiplication suppression against the control. The observations were made in dynamics. The studies showed that the macrophage activity of the mice treated with prodigiozan after exposure to the antibiotics was reliably higher than that in the control and digestion of the microbes located inside the cells started earlier, providing more complete phagocytosis.
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
June 1968,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
November 1977,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
January 1979,
Mikrobiologicheskii zhurnal,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
March 1967,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
August 1967,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
July 1980,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
September 1979,
Biulleten' eksperimental'noi biologii i meditsiny,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
November 1984,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
January 1981,
Antibiotiki,
G O Popova, and
N N Vinidchenko, and
R V Mikhalevich, and
M T Sokolova, and
L N Makarovskaia
January 1963,
Antibiotiki,
