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Proteoglycans involved in the shaping of the developing brain are often preserved in the adult brain in more restricted locations. We have studied the fate of DSD-1-PG, a chondroitin sulfate proteoglycan containing the hybrid epitope DSD-1. DSD-1-PG exerts neurite outgrowth promoting activity and has been shown to occur in the developing brain during late brain development and into adulthood. In the adult rat brain, monoclonal and polyclonal antibodies against DSD-1-PG labelled only the circumference of a selected subpopulation of neurons. These nerve cells invariably expressed the calcium-binding protein parvalbumin. The label occupied the extracellular space in close vicinity to the cell body, surrounding axon terminals and glial end feet, but was absent from synaptic clefts. DSD-1-PG is thus shown to be an additional representative of the growing list of substances found in perineuronal locations in the adult mammalian brain.
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