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We evaluated the effect of the specific cholecystokinin (CCK) receptor antagonist, loxiglumide, on gallbladder contractile function in guinea pigs. Five mg/kg body weight (BW) of loxiglumide was administered orally to guinea pigs once a day for 3 days. We then investigated gallbladder contractile function and plasma CCK concentrations in the guinea pigs. Maximal gallbladder pressure induced by cerulein was significantly depressed on the 1st and 3rd days following loxiglumide administration. On the 1st day, the plasma CCK concentration was significantly increased compared with that of the control group during fasting and 15 min after the administration of an intraduodenal test meal. These results suggest that the disturbed gallbladder contraction is due to the competitive inhibition of CCK by loxiglumide. Gallbladder contractile function in guinea pigs is depressed by loxiglumide; however, this effect is reversible after short-term loxiglumide administration.
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
April 1995,
Pancreas,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
July 1994,
Pancreas,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
June 1990,
British journal of clinical pharmacology,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
December 1990,
Gastroenterology,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
May 1990,
Pancreas,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
November 1994,
European journal of pharmacology,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
January 1998,
Arzneimittel-Forschung,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
February 1991,
Regulatory peptides,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
October 1993,
Digestive diseases and sciences,
K Tsubo, and
M Arai, and
H Omachi, and
K Mitamura
May 1990,
Gastroenterology,
