Biomaterial Database

[Denervation of the cervical sympathetic nerve inhibited the splenic natural killer cell activity in rats]. 1996

M Okada, and S Y Guo, and T Hisamitsu

Department of Anesthesiology, Toranomon Hospital, Tokyo.

Repeated applications of stellate ganglion block (SGB) are known to improve symptoms of allergic rhinitis but the mechanism of the effects is not clear. Correlation between nervous system and immune system has been reported. To examine if the blockade of a part of the sympathetic nervous system like SGB could affect immune system activity of whole body, YAC 1 cell lytic activities of the splenic natural killer cell (NK activity) were compared between the sham operation group (n = 12) and the cervical sympathetic denervation group (n = 10) 4 weeks after the operation. NK activity of denervation group was significantly lower than that of sham group. The result suggests the possibility of modulation of the immune activity of individuals by partial blockade of the sympathetic nervous system.

UI	MeSH Term	Description	Entries
D007694	Killer Cells, Natural	Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.	NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008297	Male		Males
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013562	Sympathectomy	The removal or interruption of some part of the sympathetic nervous system for therapeutic or research purposes.	Denervation, Sympathetic,Sympathetic Denervation,Denervations, Sympathetic,Sympathectomies,Sympathetic Denervations
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus