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A simple method to determine hippuric acid in urine by high pressure liquid chromatography is described. An ion exchange column is used for the separation. The detection is carried out with a photometer. The analytical criteria of the reliability of the method are tested. The results for the precision and the accuracy of the method meet the guidelines of the statistical quality control. 34 urinary constituents were tested for their interference in order to examine the specificity. Measuring urine samples from 46 normal persons yielded hippuric acid concentrations between 160 and 2010 mg/1. The median was 400 mg/1, equivalent to 357 mg/g creatinine. These results are compared to those given in the literature. Comparative investigations of those urine samples by a gas chromatographic method matched well, with a coefficient of regression of 0.86.
K Gossler, and
K H Schaller, and
W Zschiesche
January 1988,
IARC scientific publications,
K Gossler, and
K H Schaller, and
W Zschiesche
January 1977,
Sangyo igaku. Japanese journal of industrial health,
K Gossler, and
K H Schaller, and
W Zschiesche
March 1978,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
K Gossler, and
K H Schaller, and
W Zschiesche
November 1977,
Sangyo igaku. Japanese journal of industrial health,
K Gossler, and
K H Schaller, and
W Zschiesche
May 1977,
Journal of chromatography,
K Gossler, and
K H Schaller, and
W Zschiesche
May 1977,
Sangyo igaku. Japanese journal of industrial health,
K Gossler, and
K H Schaller, and
W Zschiesche
September 1980,
Archives of toxicology,
K Gossler, and
K H Schaller, and
W Zschiesche
February 1981,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
K Gossler, and
K H Schaller, and
W Zschiesche
January 1978,
Arzneimittel-Forschung,
K Gossler, and
K H Schaller, and
W Zschiesche
November 1986,
Sangyo igaku. Japanese journal of industrial health,
