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The presence of mycotoxins in grains and feedstuffs causes not only animal health problems, but also a valid concern about the transmission of potentially toxic residues into animal-derived products intended for human consumption. In a series of studies at Agriculture and Agri-Food Canada, we investigated the biological fate of fumonisin B1 (FB1) in several food-producing animals (grower pigs, laying hens, dairy cattle), as well as monitored various parameters for evidence of toxicity in these species. In several experiments involving either single-dose protocols (iv, po) or longer-term feeding trials, the pharmacokinetic profiles of FB1 (purity > 95%) in these species were determined, including tissue accumulation and transmission of residues. Toxicological (and economical) implications such as performance (feed consumption, growth), productivity, and carcass quality were also measured when appropriate.
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
March 2021,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
May 2002,
Food additives and contaminants,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
February 2015,
International journal of food sciences and nutrition,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
January 2005,
Bulletin of environmental contamination and toxicology,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
January 1995,
Natural toxins,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
June 2006,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
January 1998,
Food additives and contaminants,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
January 2012,
IARC scientific publications,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
March 1999,
The Veterinary clinics of North America. Food animal practice,
D B Prelusky, and
H L Trenholm, and
B A Rotter, and
J D Miller, and
M E Savard, and
J M Yeung, and
P M Scott
December 1951,
Journal of the American Medical Association,
