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We have reported tissue distribution studies in rats and dogs with a new adrenal imaging agent. 131I-6beta-iodomethyl-19-nor-cholesterol (NP-59). This agent concentrated five times higher in the adrenal cortex than 131I-19-iodocholesterol without increased concentration in non-adrenal tissues. We now report in 34 patients, the findings on scintigraphy with NP-59 compared with angiograms and/or adrenal vein hormone levels and histopathology, including 13 patients with hypercortisolism, 12 with primary aldosteronism, 2 with low renin hypertension, 5 with catecholamine excess, 1 with a liver metastasis from an aldosterone producing adrenal cortical carcinoma, and 1 with anaplastic adrenal cortical carcinoma. NP-59 adrenal cortical uptake was more rapid and intense and background activity was less prominent, allowing earlier and more definite interpretation of images than was possible with 131I-19-iodocholesterol.
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S D Sarkar, and
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S D Sarkar, and
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S D Sarkar, and
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RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
S D Sarkar, and
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R Cooper, and
E N Gold
July 1979,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S D Sarkar, and
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R Cooper, and
E N Gold
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Nuclear medicine communications,
