Biomaterial Database

Evaluation of tetracycline in the neutrophil chemotactic response. 1977

J A Majeski, and J W Alexander

The chemotactic response of human neutrophils was examined in the presence of tetracycline. High concentrations of the antibiotic decreased chemotaxis in vitro but did not have an inhibitory effect on the ability of neutrophils to respond to the chemotactic components of human complement. Mixtures of human serum and endotoxin had decreased chemotactic ability when they were preincubated with various concentrations of tetracycline, the decrease being concentration dependent. This inhibitory effect of tetracycline on the chemotactic response of human neutrophils was not time dependent. Eight different tetracycline compounds were found to produce similar inhibitory effects on the chemotactic response of human neutrophils in vitro. The results indicated that tetracycline either inhibits the generation of neutrophil chemotactic factors of human serum or binds with the chemotactic factors after their generation to cause inactivation.

UI	MeSH Term	Description	Entries
D009504	Neutrophils	Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.	LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D002634	Chemotaxis, Leukocyte	The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.	Leukotaxis,Leukocyte Chemotaxis
D003864	Depression, Chemical	The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.	Chemical Depression,Chemical Depressions,Depressions, Chemical
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013752	Tetracycline	A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.	4-Epitetracycline,Achromycin,Achromycin V,Hostacyclin,Sustamycin,Tetrabid,Tetracycline Hydrochloride,Tetracycline Monohydrochloride,Topicycline,4 Epitetracycline