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The pharmacokinetics of inhaled carbon disulfide (CS2) vapor was evaluated in rats. Estimates of free CS2 and its nonvolatile, acid-labile metabolites (AL CS2) were made in a variety of rat tissues after an 8-hour inhalation exposure to CS2 vapor (2 mg/l of air). At the end of the exposure, all tissues examined contained appreciable amounts of the native solvent and AL CS2. Elimination of CS2 from the rat during the postexposure period was rapid and occurred primarily via the lungs. Excretion of AL CL2 occurred primarily via the kidneys and was prolonged with respect to that of free CS2. Accumulation of these metabolites upon repeated exposures and their presence in all tissues examined suggest that they may play a role in the toxicity of CS2.
M J McKenna, and
V DiStefano
January 1963,
Arhiv za higijenu rada i toksikologiju,
M J McKenna, and
V DiStefano
May 1974,
Life sciences,
M J McKenna, and
V DiStefano
January 1978,
Biochemical pharmacology,
M J McKenna, and
V DiStefano
February 1987,
Biochemical pharmacology,
M J McKenna, and
V DiStefano
April 1958,
Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete,
M J McKenna, and
V DiStefano
January 1954,
Annali della sanita pubblica,
M J McKenna, and
V DiStefano
July 1988,
Research communications in chemical pathology and pharmacology,
M J McKenna, and
V DiStefano
January 1986,
Acta pharmacologica et toxicologica,
M J McKenna, and
V DiStefano
January 1963,
Polskie Archiwum Medycyny Wewnetrznej,
M J McKenna, and
V DiStefano
August 1981,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
