We compared the effects of normothermic (NCPB, N = 5) and moderate hypothermic (HCPB, (N = 5) cardiopulmonary bypass on cerebral oxygen metabolism in patients undergoing coronary artery bypass grafting. For monitoring of cerebral oxygenation, we used jugular venous oxyhemoglobin saturation (SjVO2) and near infrared spectroscopy (NIR). In NCPB group, although SjVO2 decreased temporally at the start of cardiopulmonary bypass, it became stabilized above 50% during the rest of cardiopulmonary bypass. In HCPB group, on the contrary, oxyhemoglobin measured by NIR showed maximum decrease during rewarming under cardiopulmonary bypass. Furthermore, SjVO2 decreased under 50% at the end of cardiopulmonary bypass (3/5 cases). We consider that NCPB is a useful technique for preventing cerebral hypoxia, if the decrease of SjVO2 during the early period of cardiopulmonary bypass is avoidable. Lastly, we also advocate that both SjVO2 and NIR are useful monitoring systems for continuous evaluation of cerebral oxygen metabolism during cardiopulmonary bypass.