-transparent.png){kind=logo}
The aim of this study is to evaluate the nephrotoxicity of two contrast media (CM), with different physicochemical characteristics: diatrizoate (ionic high-osmolar), iopromide (nonionic low-osmolar). Intravenous urography was performed in 34 patients: 17 were examined with diatrizoate and 17 with iopromide, randomly assigned. Different parameters of glomerular and tubular function were measured before and at 6, 24, and 48 h after urography. Both contrast media induced a reversible increase of urine enzymes, which was significantly higher after diatrizoate. In particular, diatrizoate determined a relevant increase of brush border enzymes gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) and of cytosolic enzyme lactate dehydrogenase (LDH), while, after iopromide increases of urinary enzymes were less evident and were significant only for GGT and ALP. In addition, diatrizoate affected other tubular functions (clearances of phosphorus and uric acid) and slightly decreased glomerular function in a few patients. In no case did these glomerular and tubular effects have a clinical relevance. In conclusion, the nonionic low-osmolar contrast medium iopromide appeared less nephrotoxic than diatrizoate. The cost-benefit ratio needs further examination.
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
January 1988,
Contributions to nephrology,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
January 1999,
The Science of the total environment,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
January 1989,
Advances in experimental medicine and biology,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
November 1998,
Acta radiologica (Stockholm, Sweden : 1987),
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
January 1990,
Contributions to nephrology,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
February 1961,
Annals of surgery,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
November 1984,
Contact dermatitis,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
May 1985,
International journal of cardiology,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
June 1990,
Kokyu to junkan. Respiration & circulation,
C Donadio, and
A Lucchesi, and
G Tramonti, and
A Calderazzi, and
G Gibilisco, and
A Paolicchi, and
R Giordani, and
C Bianchi
May 1994,
Investigative radiology,
