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The anti-cancer activity of dimers joined with ether, ester or carbon-carbon bonds by photodynamic therapy (PDT) was compared by using DBA/2 mice transplanted with SMT/F tumors. Dimers with ether and carbon-carbon linkages were found to be more effective than those linked with ester bonds. Variation of the substituents at peripheral positions made a significant difference in in vivo efficacy. Among the ether and carbon-carbon linked dimers, the divinyl analogs were found to be most effective. The preliminary in vivo results also suggest that the position(s) of the hydrophilic substituents in the molecules make a remarkable difference in photosensitizing activity. An unsymmetrical dimer with an amide linkage, obtained from 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) was found to be less effective than HPPH.
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
May 1986,
Cancer research,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
May 2013,
Organic & biomolecular chemistry,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
October 2018,
Chembiochem : a European journal of chemical biology,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
August 2022,
Scientific reports,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
July 2001,
Phytochemistry,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
January 2002,
Journal of biomaterials science. Polymer edition,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
March 2012,
Photodiagnosis and photodynamic therapy,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
January 2013,
The Journal of organic chemistry,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
April 1989,
Cancer research,
R K Pandey, and
G Zheng, and
D A Lee, and
T J Dougherty, and
K M Smith
November 2005,
Journal of colloid and interface science,
