Biomaterial Database

Corneal coloboma, aphakia and retinal neovascularization with anterior segment dysgenesis (Peters' anomaly). 1996

C A Gunderson, and R Stone, and R Peiffer, and S Freedman

Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27599-7040, USA.

An infant with bilateral Peters' Anomaly, with corneal opacification in the right eye and an opacification with an axial defect in the left also had an associated hydrocephalus and cardiac anomalies that proved fatal; histopathology of the right eye showed retinal neovascularization in addition to findings consistent with a diagnosis of Peters' Anomaly; in the left eye, pathologic findings were suggestive of a corneal coloboma associated with aphakia.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297	Male		Males
D003103	Coloboma	Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.	Coloboma Of Iris, Choroid, And Retina,Coloboma, Ocular,Coloboma, Uveoretinal,Ocular Coloboma,Uveoretinal Coloboma,Colobomas,Colobomas, Ocular,Colobomas, Uveoretinal,Ocular Colobomas,Uveoretinal Colobomas
D003315	Cornea	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)	Corneas
D003318	Corneal Opacity	Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.	Leukoma,Corneal Opacities,Leukomas,Opacities, Corneal,Opacity, Corneal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000015	Abnormalities, Multiple	Congenital abnormalities that affect more than one organ or body structure.	Multiple Abnormalities
D000869	Anterior Eye Segment	The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.	Anterior Eye Segments,Eye Segment, Anterior,Eye Segments, Anterior,Segment, Anterior Eye,Segments, Anterior Eye
D001035	Aphakia	Absence of crystalline lens totally or partially from field of vision, from any cause except after cataract extraction. Aphakia is mainly congenital or as result of LENS DISLOCATION AND SUBLUXATION.	Aphakic Eye,Aphakic Eye, Post-traumatic,Aphakic Eye, Traumatic,Aphakias,Aphakic Eye, Post traumatic,Aphakic Eyes,Aphakic Eyes, Post-traumatic,Eye, Aphakic,Eye, Traumatic Aphakic,Post-traumatic Aphakic Eye,Post-traumatic Aphakic Eyes,Traumatic Aphakic Eye,Traumatic Aphakic Eyes
D015861	Retinal Neovascularization	Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.	Neovascularization, Optic Disc,Neovascularization, Retinal,Optic Disc Neovascularization,Optic Disk Neovascularization,Sea Fan Neovascularization,Disk Neovascularization, Optic,Neovascularization, Optic Disk,Neovascularization, Sea Fan,Optic Disc Neovascularizations,Optic Disk Neovascularizations,Sea Fan Neovascularizations