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The aim of this study was to investigate whether nitric oxide (NO) is involved in cardiorespiratory regulation in the nucleus tractus solitarii (NTS). Unilateral microinjections (50 nl) of the NO-donor, sodium nitroprusside (SNP, 40-100-200 mM), into the NTS of anaesthetized rats elicited dose-dependent apnea (7.3 +/- 2.3 sec; 28.6 +/- 5.7 sec; 35.6 +/- 6.4 sec, respectively; n = 6) and a decrease in arterial blood pressure (8.4 +/- 3.1 mmHg; 18.2 +/- 5.8 mmHg; 25.8 +/- 6.7 mmHg, respectively; n = 6). Similarly, unilateral micro-injections (50 nl) of another NO-donor, 3-morpholinosydnonimine (SIN-1, 20-40-100 mM), also induced apnea (5.1 +/- 2.4 sec; 8.7 +/- 4.3 sec; 26.3 +/- 6.4 sec, respectively; n = 6) and a decrease in arterial blood pressure (6.2 +/- 2.3 mmHg; 11.1 +/- 3.3 mmHg; 18.3 +/- 6.1 mmHg, respectively; n = 6). The SNP- and SIN-1-induced apnea and arterial blood pressure decrease were significantly (p < 0.01) blocked by a 3 min pretreatment with two calcium-channel blockers, diltiazem (0.1 mM) and cobalt (10 mM), while lower doses (diltiazem 0.01 and cobalt 1) were ineffective. Microinjections of diltiazem (0.01 mM) and cobalt (1 mM) alone did not induce any change in basal cardiorespiratory values like diltiazem (0.1 mM) and cobalt (10 mM). These data suggest that NO may be involved in NTS cardiorespiratory regulation via calcium-channel activation.
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
October 2000,
European journal of pharmacology,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
July 1992,
Physiological reviews,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
April 1997,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
December 1998,
Hypertension (Dallas, Tex. : 1979),
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
May 1998,
Neuroscience,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
July 2006,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
January 2001,
Neuroscience,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
July 1995,
The Journal of physiology,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
March 2005,
Journal of chemical neuroanatomy,
S Vitagliano, and
L Berrino, and
M D'Amico, and
S Maione, and
V De Novellis, and
F Rossi
February 2000,
Brain research,
