BIOMAT Database Logo BIOMAT Database Logo

Xanthoma disseminatum. Clinical, metabolic, pathologic, and radiologic aspects. 1977

M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams

A 55-year-old man with the classical mucocutaneous lesions of xanthoma disseminatum has been followed up for a period of 13 years. The special features of this case, which make it unique, are as follows: (1) the availability of histologic data on multiple lesions for more than a ten-year period; (2) the progressive nature of the multiple osseous lesions; (3) the metabolic studies that show no evidence for accumulation of abnormal sterols in a xanthoma, the blood, or intestinal aspirate; (4) the development of hypothyroidism and symptoms or signs, or both, of an intracerebral and an intraspinal lesion; (5) the partial regression of the cutanous symptoms and lesions while receiving clofibrate, in spite of progression of the mucous membrane and osseous lesions, and (6) the failure to develop diabetes insipidus to date.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009059 Mouth Diseases Diseases involving the MOUTH. Disease, Mouth,Diseases, Mouth,Mouth Disease
D009061 Mouth Mucosa Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations. Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D009092 Mucous Membrane An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa. Lamina Propria,Mucosa,Mucosal Tissue,Muscularis Mucosae,Mucous Membranes,Membrane, Mucous,Membranes, Mucous,Mucosae, Muscularis,Mucosal Tissues,Propria, Lamina,Tissue, Mucosal,Tissues, Mucosal
D011859 Radiography Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film). Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D002994 Clofibrate A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) Athromidin,Atromid,Atromid S,Clofibric Acid, Ethyl Ester,Ethyl Chlorophenoxyisobutyrate,Miscleron,Miskleron,Chlorophenoxyisobutyrate, Ethyl

Related Publications

M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
April 1992, International journal of dermatology,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
January 1985, Journal of the Royal Society of Medicine,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
June 1974, Proceedings of the Royal Society of Medicine,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
December 2002, International journal of dermatology,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma Disseminatum.
January 1986, Indian journal of dermatology, venereology and leprology,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
January 2018, Lancet (London, England),
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
January 1986, Indian journal of dermatology, venereology and leprology,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
December 1990, International journal of dermatology,
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
October 1993, Archives of ophthalmology (Chicago, Ill. : 1960),
M A Mishkel, and W P Cockshott, and D J Nazir, and D Rosenthal, and W P Spaulding, and A Wynn-Williams
Xanthoma disseminatum.
March 1947, Archives of dermatology and syphilology,
Copied contents to your clipboard!