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Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. 1996
C I Rosenblum, and
M Tota, and
D Cully, and
T Smith, and
R Collum, and
S Qureshi, and
J F Hess, and
M S Phillips, and
P J Hey, and
A Vongs, and
T M Fong, and
L Xu, and
H Y Chen, and
R G Smith, and
C Schindler, and
L H Van der Ploeg
Department of Genetics & Molecular Biology, Merck Research Laboratories, Merck & Co., Rahway, NJ 07065, USA.
The leptin receptor (OB-R) bears homology to members of the class I cytokine receptor family. We demonstrate that leptin binding to OB-R stimulates formation of STAT-1 and STAT-3 complexes, thereby defining transcriptional motifs for genes that are under leptin control. Transfected fa OB-R bound leptin with equal affinity to that of wild type OB-R. fa OB-R abundance was about 7 fold reduced compared to control cells. Surprisingly, the low level of fa OB-R is fully capable of activating the STAT signal transduction pathway. We discuss plausible explanations for the obese phenotype in Zucker fatty rats.
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