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Foamy viruses are retroviruses of the spumavirus family that are often isolated from primary cultures of primate cells. We previously constructed vectors based on human foamy virus (HFV) and found that they were able to transduce a wide variety of vertebrate cells by integration of the vector genome. Here we show that several types of hematopoietic cells are efficiently transduced by an HFV vector that encodes alkaline phosphatase (AP). These cell types include transformed cell lines and primary hematopoietic progenitors from mice, baboons, and humans. The transduction rates of HFV vectors compare favorably with those obtained by murine leukemia virus vectors, which suggests that HFV vectors may be effective in the treatment of hematologic diseases by gene therapy.
R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
October 2007,
Molecular therapy : the journal of the American Society of Gene Therapy,
R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
September 2010,
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R K Hirata, and
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D W Russell
December 2002,
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R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
April 2008,
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R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
January 2003,
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R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
January 1996,
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R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
August 2001,
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R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
January 2004,
Human gene therapy,
R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
June 2002,
Proceedings of the National Academy of Sciences of the United States of America,
R K Hirata, and
A D Miller, and
R G Andrews, and
D W Russell
March 2004,
Journal of virology,
