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The basal ganglia are thought to be involved in the primary dystonias, largely because of the repeated demonstration of neuropathological changes in these nuclei in the secondary dystonias. A hyperactivity of a network involving basal ganglia has been suggested in experimental animal dystonia. To test this hypothesis in humans, we studied the functional correlates of primary cervical dystonia using [18F]FDG and PET. METHODS Regional cerebral glucose metabolism (rCMRglc) was measured in 10 patients with idiopathic torticollis (6 drug-free and 4 drug-naive) and in 15 normal controls, using 2-[18F]-fluoro-2-deoxy-D-glucose ([18F]FDG) and positron emission tomography (PET). RESULTS A significant hypermetabolism in the basal ganglia, thalamus, premotor-motor cortex and cerebellum in the patients compared with normal controls was found. The patients were correctly assigned to their clinical category by a discriminant function analysis with a total accuracy of 96%. CONCLUSIONS The results support the hypothesis that a dysfunction of a subcortical-cortical motor network may play a role in the pathogenesis of focal dystonia, in agreement with the experimental dystonia models.
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
January 1979,
Applied neurophysiology,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
January 1995,
Brain research. Brain research reviews,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
January 2007,
Parkinsonism & related disorders,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
November 2021,
Neuron,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
January 2019,
Handbook of clinical neurology,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
September 2022,
Cell reports,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
June 1998,
Journal of psychosomatic research,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
March 1971,
Journal of psychosomatic research,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
September 1990,
Neurology,
G Galardi, and
D Perani, and
F Grassi, and
S Bressi, and
S Amadio, and
M Antoni, and
G C Comi, and
N Canal, and
F Fazio
July 1997,
Movement disorders : official journal of the Movement Disorder Society,
