-transparent.png){kind=logo}
Cultures of beating rat myocardial cells brought into contact with various human sera during 24 hours were infused with isoprenaline. The isoprenaline-induced positive chronotropic effect (IIPCE) was not found with all sera. IIPCE was present in all the male sera, but was absent in the cases of clinically beta-blocked pindolol treated men. IIPCE was present only in about 50% of the female sera, menopaused or not. IIPCE was absent in 95% of the sera of pregnant women in the late phase of pregnancy. This suggests the presence in female sera, especially during pregnancy, of a circulating factor capable of "in vitro" inhibition of isoprenaline-induced positive chronotropic effect.
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
September 1979,
European journal of pharmacology,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
October 1978,
European journal of pharmacology,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
December 1991,
European heart journal,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
January 1984,
Developmental pharmacology and therapeutics,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
December 2000,
Journal of pharmaceutical sciences,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
June 2007,
Biochimica et biophysica acta,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
March 1992,
European journal of pharmacology,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
October 1980,
Journal of pharmacobio-dynamics,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
January 2012,
Frontiers in physiology,
A Carli, and
M C Auclair, and
G Bleichner, and
S Weber, and
J F Monsallier, and
P Lechat
February 1974,
Toxicology and applied pharmacology,
