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Synthesis and quantitative structure-activity relationships of antihyperlipaemic 2-substituted thieno[3,2-d]pyrimidin-4(3H)-ones. 1996
C J Shishoo, and
K S Jain, and
I S Rathod, and
B J Thakkar, and
S B Brahmbhatt, and
T P Gandhi, and
R Bangaru, and
R K Goyal
L. M. College of Pharmacy, Ahmedabad, India.
The synthesis, antihyperlipaemic evaluation and quantitative structure-activity relationships (QSAR) of two series of thieno[3,2-d]pyrimidin-4-one derivatives are reported. While most of the compounds in these series were found to exhibit antihyperlipaemic activity, the QSAR study of these two series indicated a positive influence of only the electronic nature of the 2-substitutents on the biological activity. The lipophilic and the steric parameters did not appear to be significant.
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